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Still, "the potential to use human cells while recapitulating the complex mechanical features and chemical microenvironments of an organ could provide a truly revolutionary paradigm shift in drug discovery," he says.
By recapitulating the complex microenvironment that exists in the native heart, cardiac microphysiological systems have the potential to provide a more accurate pharmacological response compared to current standards in preclinical drug screening.
However, cell lines are clonally homogenous and are not recapitulating the complex tumor microenvironment in vivo.
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The integrated smoking system recapitulates the complex oxidant-induced biological responses of normal lung cells to toxic molecules present in cigarette smoke as well as COPD-specific inflammatoresponsesses.
Part steamer trunk, part altar, part collector's cabinet, it contains an elaborate installation work that recapitulates the complex life of Mr. Schurmann, a well-known German photography collector.
Moving forward, new methods to quickly generate animal models that recapitulate the complex genetics of human hematological disorders are needed to transform the genetic information to new therapies.
Standard cell culture systems have limited biological relevance because they do not recapitulate the complex 3-dimensional interactions and biophysical cues that characterize the in vivo environment.
The predictive capabilities of existing in vitro models are limited by their inability to recapitulate the complex process of drug metabolism at the multi-organ level in vivo.
They're born late in brain development, and they're challenging to generate alongside human neurons and other brain cells in a way that recapitulates the complex interactions occurring among these cell types as they develop.
They're born late in brain development, and they're challenging to generate alongside... other brain cells in a way that recapitulates the complex interactions occurring among these cell types as they develop.
While cell lines, genetically engineered murine models, and xenografts have all led to valuable clinical insights, organotypic culture models have emerged as tractable systems to recapitulate the complex 3D organization of PDA.
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