The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function.
BA/F3 used in this study grow independently of interleukin-3 when expressing the BCR/ABL oncoprotein and have been previously demonstrated to recapitulate not only the events leading to BCR/ABL-induced leukemogenesis but also the therapeutic effects of TKIs.
The horrors of the Christie murders are recapitulated, not only to convey the sadism of a deranged serial killer, but also to depict the horrors of life in Britain under the shadow of repressive legislation and morality, a Britain struggling to break free from an intrinsically Victorian mould.
The future of drug therapies depends on the development of animal models that strongly recapitulate the disease, not only to discover the mechanisms of disease but also to identify new neuroprotective drugs and to test their efficacy.
We show that our model not only recapitulates current knowledge in synaptic patterning but also identifies novel alleles overlooked by traditional methods.
This data not only recapitulates the function of CEP290 as a potent cilia stabilisation factor, but also indicates that the R1747Q mutation alters the ability of CEP290 to execute this function.
Our approach not only recapitulated the basics of muscle development and physiology, as the obtained myotubes showed qualities similar to those seen in striated muscle fibers in vivo, but also allowed for the synthesis of populations of myotubes which assumed distinct morphology, myofibrillar development and Ca2+ dynamics.
Quantitative mass spectrometry not only recapitulated known inhibitory postsynaptic proteins but also revealed a large network of new proteins, many of which are either implicated in neurodevelopmental disorders or are of unknown function.
Epidermal cells, isolated by combining these two methods, not only recapitulate a functional epidermis, but also show multipotency when injected into a developing mouse blastocyst [ 6, 16].
Interestingly, docking of BAF1 onto full-length Aβ fiber not only recapitulated the initial binding mode found in previous Aβ16 21 docking step but also revealed the different binding mode with comparable binding energies.
