This idea predicts, first, that biomarkers of social stress should also be biomarkers of aging and, second, that the direction of social stress effects on these biomarkers should recapitulate changes with age (Bauer, 2008).
Levels of phosphorylated NF-kB were moderately increased by stimulation with rTNF and were more elevated in the patient versus the control sample in some cell subsets (natural killer cells and CD4 T cells) but not in others, while phosphorylated Erk1/2 levels recapitulated changes seen in phosphorylated p38.
Many cancers stimulate an inflammatory response associated with changes in ECM components that recapitulate the changes of chronic inflammation (Coussens and Werb, 2002).
But even those who disagree with the result say Abzhanov and his student Bhart-Anjan Bhullar, now a postdoctoral fellow at the University of Chicago, have demonstrated a powerful new approach: pinning down how the anatomy changed using fossils, then trying to recapitulate the changes in the lab by tinkering with genetic signals.
These data show that diet- and age-influenced changes in metabolome remodeling throughout lifespan closely recapitulated transcriptional changes and progression of aging.
Several of the EtoL regions recapitulated developmental changes that occur during ES cell differentiation, raising the possibility that the observed changes might be an indirect result of cell differentiation after BAF250a loss.
We also find that we can computationally recapitulate specificity changes upon mutation, a key test for successful forward design of protein protein interface specificity.
We present specific albeit modest changes in the DS brain's splicing machinery with subsequently amplified effects in target transcripts; and we demonstrate that engineered excess of Dyrk1A can largely recapitulate these changes.
We have previously described a cardiomyopathy induced by culturing ventricular myocytes from normal adult rats in a medium containing high concentrations of glucose, which recapitulates cellular changes associated with early onset diabetic cardiomyopathy.
We thus tested two different EPS conditions and studied three different cell systems to establish stimulation conditions that recapitulate plastic changes on the gene expression level.
