Bacon argues against "anticipation of nature", which he regards as a conservative method, leading to theories that recapitulate the data without producing new ones conducive to the growth of knowledge.
First, we were able to recapitulate the data about the complex formation containing ERα/Src/PI3K that were obtained with other techniques.
At the same time, noise trajectories predicted by assuming the incorrect, reverse topology (Hsp12 activates Msn2) cannot recapitulate the data (correlation of −0.15).
Moreover, there was a significant relationship between increasing ERK5 protein expression and increasing Mcm2 (P=0.003) and Ki67 (P=0.009) expression (Table 1), recapitulating the data generated in the in vitro tissue culture model system.
Finally, mathematical modeling of the subunit exchange reaction based on this evidence closely recapitulates the experimental data.
In most cases, the ES data recapitulated the WGS data: for example, both personal genome approaches identified 12 pharmacologically relevant variants (that is, pharmacogenetic traits) (Table 2).
Integration of the single- and multiple-dose PK data into a pop PK model established a predictive simulation tool that effectively recapitulated the observed data and provided a foundation for integrating subsequent clinical PK data for identifying novel dose levels and/or regimens.
Moreover, it was possible to use the Exon array data to design assays using the alternate QuantiGene platform, which recapitulated the original data and stratified cervix samples into histological categories, as expected.
Thus, although the model qualitatively recapitulated the training data, many of the parameters were poorly constrained (Fig. 2B).
The family of models simultaneously recapitulated the training data and predicted total inositol levels following GPCR activation.
