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In this study (Rhim et al., 2014), mice were treated for an extended period of time, and the preclinical data recapitulated what was seen in the clinic, with inhibition of Hh signalling decreasing survival rather than improving it.
Combined inhibition of PI3K signaling and autophagy using individual siRNAs against p110α and Vps34 or using pharmacological type I and type III PI3K inhibitors recapitulated what was seen with EZN4150, and robustly enhanced tumor cell killing.
4) Discussion (text): In a second text excerpt, the intervention is recapitulated (What was done) and arguments in favour (pro) and against (con) the presented intervention are discussed in a concluding discussion.
As for HeLa cells, we found that the primary ciliogenesis regulators tested were not required for perinuclear dynein in RPE cells: loss of CETN2 or PCTN recapitulated what was observed in NT-siRNA cells (with PC formation in 76% and 78%, respectively, of siRNA-treated cells; Fig. 3B,D).
The phenotype of emb-1 in combination with the reduction-of-function APC/C mutants emb-27, mat-2, mat-3, or the CDC-20 ortholog, fzy-1, recapitulated what we have seen with APC/C double mutants (Table 2); double mutant lines could not be maintained at the permissive temperature.
Similar(53)
No one conveniently recapitulates what is known and not known.
It's just yak, yak, yak for 100 minutes, as Bogart ceaselessly recapitulates what is taking place offscreen.
He plans to recapitulate what is known and not known about the terrorism already inflicted on the nation.
In an uncanny way, he said, he felt that he was recapitulating what had happened with his mother.
"People want to see both," said Steve Lombardo, chief executive at Strategy One, part of the Edelman Public Relations Worldwide division of Daniel J. Edelman Inc. "They want to move forward rather than recapitulate what happened," he added, but they also want marketers to be sensitive to the new environment.
The journey to Venice, toward the end of "In Search of Lost Time," recapitulates what's been a major theme in Proust's novels: people arouse the most passion when they are not possessed, places the most passion when they are not visited.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com