The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function.
BA/F3 used in this study grow independently of interleukin-3 when expressing the BCR/ABL oncoprotein and have been previously demonstrated to recapitulate not only the events leading to BCR/ABL-induced leukemogenesis but also the therapeutic effects of TKIs.
However, this relationship is not recapitulated in the concatenated, species level, phylogeny (Fig. 2, Supplementary Fig. S3).
Additionally, PAPP-A2 cannot be detected in cord blood demonstrating that the alterations in maternal and placental PAPP-A2 are not recapitulated in the fetal circulation.
Indeed, there was hardly a subject that has aroused dem onstrators in the last five years that was not recapitulated in the course of the day.
In some instances, murine models of allergic asthma have not recapitulated the human findings, and have led to some costly failures in drug development.
However, these observations are not recapitulated on application of transmural pressure (PTM) oscillations (that mimic tidal breathing and DIs) in isolated intact airways.
Interestingly, whereas thrombospondin-1-deficient dendritic cells augmented activity of allergen-primed T cells, this increase was not recapitulated with naïve T cells in vitro.
The ropB mutation of strain 5628 was not recapitulated on passage in the mouse subcutaneous infection model.
In addition to the usual caveats of overexpression data, this result was not recapitulated by the same group when using a different plasmid system [22].
