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Treatment options are limited, and few experimental models recapitulate the key features of the condition.
A mouse model of MLIV created in our laboratory was shown to accurately recapitulate the key features of the human disease [ 25].
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This novel cellular system recapitulates the key features of PD namely dysfunction and death in ageing midbrain neurons.
Inactivation of cathepsin D in flies results in age-dependent neurodegeneration and recapitulates the key features of neuronal ceroid lipofuscinoses, a family of lysosomal storage disorders [42].
As Fig. 5B shows, the temporal profile predicted by the GRN model recapitulates qualitatively the key features, notably the counter-intuitive non-monotonical behaviour of key TFs.
Neurotoxins-based models of PD have a long history and represent the most important models while genetic animal models have failed to recapitulate the key neurobehavioral or pathological features of PD [ 10, 11].
An ideal model should recapitulate the key histopathological, genetic and imaging features encountered in GBM's aggressive growth as well as being a reproducible, reliable model.
Nevertheless, animal models cannot fully recapitulate the key aspects of human models [ 71].
Below, we recapitulate the key aspects of these mechanisms (and obtain rough estimates for key observables), which constitute key parts of the emergent behavior reported herein.
As presented here, NHP models recapitulate most of the key features of these comorbidities.
Because important biological differences still exist between animal models and humans that could significantly impair drug discovery [ 11], although the models could usually recapitulate many of the key features in physiology.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com