Before describing our solutions based on these methods, we recapitulate the essential features of the 10320/loc implementation based on handle records.
In view of the above information, we proposed a novel approach to assess whether the animal models recapitulate the essential features of human diseases for drug research.
Through exploring the relations between drug molecules and mouse disease models, our method was able to assess whether the corresponding model recapitulates the essential features of the human disease.
The resulting model, recapitulating the essential features of in vivo neocortical development, can be used to construct in vitro models of cocaine-induced neocortical disorders and develop therapeutic strategies for the prevention of cocaine-induced impairment of brain development.
We evaluated mechanisms contributing to the adverse effects of chlorpyrifos (CPF) on DNA synthesis, cell number and size, and cell signaling mediated by adenylyl cyclase (AC) in PC12 cells, a neuronotypic cell line that recapitulates the essential features of developing mammalian neurons.
To test whether copper repression can recapitulate the loss of viability that an essential gene knockout causes, we placed P tcu-1 upstream of the essential gene, hpt-1.
Also, patient-relevant in vivo models of sufficient duration that are able to recapitulate the subclonal complexity of CLL are an essential component of preclinical drug assessment and can inform tailored treatment regimens.
Biomaterials have become an essential tool in the effort to recapitulate the chemical, physical, and spatiotemporally dynamic cell environment needed for effective biomimetic tissue engineering.
The experimental systems that recapitulate the complexity of native tissues and enable precise control over the microenvironment are becoming essential for the pre-clinical tests of therapeutics and tissue engineering.
Although no single model can recapitulate the complexities of human TBI, considered among the most heterogeneous of neurological disorders, they are essential for elucidating pathological mechanisms of injury and evaluating potential therapeutic interventions (14, 39).
In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures.
