Exact(1)
PERMANOVA relies on comparing the observed value of a test statistic (F-ratio) against a recalculated test statistic generated from random permutation of the data.
Similar(59)
Test statistic comparing group 1 and group 2 for the kth cell-type: t k 21 = β ^ k 2 − β ^ k 1 s e β ^ k 21, s e β ^ k 21 = n 1 s e β ^ k 1 2 + n 2 s e β ^ k 2 2 n 1 + n 2 The p-value for each test-statistic was calculated by generating an empirical distribution by recalculating test-statistics after reshuffling of class labels 1000 times.
During randomisation, within each network, we randomly reassigned the strength values to all nodes without replacement and recalculated the test statistic.
Individual activation maps were recalculated by testing the goodness-of-fit of this convolution with the blood oxygen level-dependent time series that used the ratio of the sum of squares of deviations from the mean intensity value due to the model (fitted time series) divided by the sum of squares due to the residuals (original time series minus model time series).
The idea of permutation test is to randomly shuffle the phenotype values among the individuals and recalculate the test statistics.
The null distribution of each of these test statistics was determined by reassigning the metabolic rates to individuals at random without replacement (i.e., shuffling the metabolic rates) 1000 times, each time recalculating the test statistic.
To estimate distributions for the test statistic, the spatial scan statistic uses the Monte Carlo method and assigns cases to individuals in the population randomly, and recalculates the test statistic.
Since four regression models were evaluated in this analysis (anemia with MDS-ADL, anemia with MDS-HSI, Hb range with MDS-ADL, Hb range with MDS-HSI) the familywise error rate was maintained as a further sensitivity test by recalculating the individual test type I error rate to α/n = 0.0125.
HLA-DRB1*03, DQA1*05 and DQB1*02 were therefore removed from the data, and the overall exact tests recalculated, after which no further overall differences were detected between myositis subtype versus controls.
A total of K random permutations are generated independently; for each permutation the group to which each subject belongs is randomly exchanged, and then the statistical test is recalculated in each permutation.
These tests are recalculated with the methods described above.
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