Exact(5)
When fit to first and subsequent episodes, both interval censoring and gap-time Cox models suggest a gradual increase in the risk of viral rebound with increasing blip magnitude rather than a threshold effect (Table 2).
In the gap-time model, the relative risk of viral rebound with increasing blip magnitude was estimated to be HR 1.08 (95%% CI 1.03 to 1.14) per 100 copies/mL.
However our data show a gradual increase in the relative risk of viral rebound with increasing blip magnitude (HR 1.09, 95%% CI 1.03 to 1.15, per 100 copies/mL of HIV RNA), rather than a threshold effect.
For example, the relative risk of viral rebound with increasing blip magnitude, estimated in our model to be HR 1.09 (95 % CI 1.03 to 1.15) per 100 copies/mL of HIV RNA, was similar in both first and subsequent suppression episodes (HR 1.11, 95%% CI 1.03 to 1.19, and HR 1.07, 95%% CI 1.00 to 1.15, per 100 copies/mL respectively).
In an analysis of data collected after May 2003, the risk of viral rebound with increasing blip magnitude was similar both in those reporting adherence and in those reporting non-adherence at the time of the blip (HR 1.04, 95%% CI 0.94 to 1.15, and HR 1.09, 95%% CI 0.93 to 1.27, per 100 copies/mL respectively).
Similar(54)
The Singular Limit Predicts a Window of Rebound Spiking with Increasing GABAa Inhibition We obtain a singular limit prediction of post-inhibitory rebound spiking by simply identifying the position of the base point of the initial condition relative to the position of the singular canard under variation of τ s. Figure 9 shows that rebound spiking is predicted for τ s ∈ [ 5, 24 ].
Mention needs to be made of the rebound effect with increasing attendances when the public education messages ceased.
In addition, a rebound in tourism was credited with increasing sales tax revenues.
Liver fibrosis progression was associated with HIV rebound, but not blips, and with increasing cumulative exposure to HIV RNA, highlighting the importance of achieving and maintaining HIV suppression in the setting of HIV/HCV coinfection.
It is observed that compression set, abrasion loss, cross-link density, and shear modulus increased, while rebound resilience and swelling ratio values decreased with increasing MS loading.
If given before pregnancy, furosemide was continued during pregnancy to reduce the risk of rebound fluid retention with increased blood pressure and UAE when discontinuing the drug (16).
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