We found a rebound of disease in 43 patients (28.6%), with a 17 months medium disease-free period.
For example, he said, although Vietnam has greatly reduced the number of bird flu outbreaks by vaccinating poultry, no one knows if the vaccine puts pressure on A(H5N1) to mutate to develop resistance to the shot, which could cause a rebound of disease in the coming years.
Does discontinuance of treatment result in a prompt rebound of disease?
8% of these patients experienced a rebound of disease shortly after discontinuation of cyclosporine.
In sharp contrast, discontinuation of anti-TNF treatment led to a prompt rebound of disease, i.e., clinical scores reached arthritic control severity in less than a week.
Natalizumab is also effective in patients with very active MS, but has the propensity to result in rebound inflammatory disease activity on withdrawal [ 8].
Cessation of antiretroviral therapy is not feasible as it may lead to viral rebound and disease progression (Costiniuk et al., 2013).
Natalizumab is also effective in patients with very active MS, but has a propensity to result in rebound inflammatory disease activity on withdrawal.
When oxaliplatin treatment is interrupted in this model, rebound of disease occurs, with clinical flare coinciding with massive extracellular HMGB1 release.
The rebound of disease activity following transient cessation of IL-1RA therapy due to opportunistic infections, was noticed in one of our patients as well as in other published cases; however, disease activity resolved after drug reinstitution in all of them [ 13, 16, 19].
Dr. Susan Desmond-Hellmann, chief medical officer at Genentech, said such a disease rebound would be less of a problem in actual treatment because drug use would not be halted as abruptly as it was in the trial.
