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np1 is a user friendly computer program which has implemented two continual reassessment methods for simulating and conducting a phase I clinical trial.
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The new design is compared to the continual reassessment method.
The continual reassessment method and its applications: a Bayesian methodology for phase I cancer clinical trials.
Many clinicians often do not feel comfortable with the Continual Reassessment Method (CRM).
A widely used approach in designing the phase I clinical trial is continual reassessment method (CRM).
Practical modifications of the continual reassessment method for phase I cancer clinical trials.
The continual reassessment method (CRM) was first introduced by O'Quigley et al. [1990. Continual reassessment method: a practical design for Phase I clinical trials in cancer. Biometrics 46, 33 48].
Application of preclinical data to initiate the modified continual reassessment method for maximum tolerated dose-finding trial.
O'Quigley, M. Pepe, L. Fisher, Continual reassessment method: a practical design for phase 1 clinical trials in cancer.
We select individual and group MTDs using Legedza and Ibrahim's extension of O'Quigley et al.'s Continual Reassessment Method.
Med. 20, 2661 2681], Legedeza and Ibrahim [2002. Longitudinal design for phase I trials using the continual reassessment method. Controlled Clin. Trials 21, 578 588], Mahmood [2001.
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