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One biological explanation for this could be that for "topographical reasons of function" the spinal cord has to be hostile to axonal sprouting by exploiting the growth-inhibiting properties of proteins as mentioned above, the inhibition of which may be a new neuroprotective strategy in EAE (Karnezis et al., 2004).
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There are many plausible reasons that gain of function mutations in CACNA1H might have effects in adrenal but not other tissues.
In particular, the potential of public reason to function as a mechanism of mutual assurance depends on how we interpret the duties that public reason imposes on ordinary citizens.
The reason of enzyme function prediction based only on sequence information is due to the easily available sequence data.
We reasoned that loss of function clones of wg would probably produce inconclusive results due to potential non-autonomous effect from surrounding wild-type ISCs.
A clear theme in both Europe and the US is the need for the scientific community to engage more broadly with the public, explaining the reasons for doing gain-of-function research.
A clear theme in both Europe and the US is the need for the scientific community to engage more broadly with the public, explaining the reasons for doing gain-of-function research, discussing the potential risks and benefits of this research, and explaining the biorisk management practices adopted.
If LET-363 acted to inhibit outgrowth downstream of DAF-18, we reasoned that a loss-of-function mutation in LET-363 would suppress the neurite truncation phenotype in a daf-18 mg198) daf-18 mg198
Restoration of TH levels could occur for multiple reasons, such as restoration of function in neurons that were damaged but still present, promoting sprouting of existing neurons, or even recruiting of new neurons from stem cells in the adjacent subventricular zone (SVZ).
The first class (A) contains the loci in which the reference allele has never been observed in 1000GP individuals and for this reason it could have loss-of-function as well as gain-of-function role.
We reasoned that screening for loss-of-function mutations that suppress the dauer-constitutive phenotype of eak-7 ; akt-1 double mutants might identify genes encoding novel DAF-16/FoxO activators.
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