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For the sake of completeness, it should be noted that there can well be other reasons for modifications, for example if there is some other dependence than a linear one for very small or very high speeds.
The database is updated annually and among other variables it contains data on: date of birth, gender, route of transmission, race, date of first HIV-1 positive test, bodyweight, immigration and emigration, date of death, date of HAART initiation, HAART regimens and reasons for modifications.
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The following information was collected at each infusion: the initial infusion rate, the number and proportion of patients with an infusion modification and the reasons for modification; the number and proportion of patients who completed the 1000-mg dose; and the total infusion times among those who completed the 1000-mg dose.
The most common reason for modification was adverse effects of GPOvir® (73.5%), followed by treatment failure (16.7%), for treatment of tuberculosis (TB) (4.2%), and pregnancy (2.7%).
Virological failure was defined as such if the physician treating the patients' HIV infection had stated virological failure as the reason for modification in the medical file.
Another reason for modification may be triggered by the fact that research practice reveals problems in interdisciplinary communication or cooperation which are not considered in the theoretical model but should, nevertheless, be integrated.
Data were collected on adverse events (AEs), treatment modifications (discontinuations, interruptions, dose changes), and reasons for these modifications.
Reasons for treatment modifications were also abstracted from patients' medical records, and only modifications that were responses to AEs were considered in this analysis.
Figure 2 shows the Kaplan-Meier estimates of regimen modification by reasons for the modification; lipodystrophy, rash and treatment failure.
The main reasons for dose modifications were non-haematological toxicities.
Moreover, this study examined reasons for treatment modifications.
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