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The following information was collected at each infusion: the initial infusion rate, the number and proportion of patients with an infusion modification and the reasons for modification; the number and proportion of patients who completed the 1000-mg dose; and the total infusion times among those who completed the 1000-mg dose.
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For the sake of completeness, it should be noted that there can well be other reasons for modifications, for example if there is some other dependence than a linear one for very small or very high speeds.
The database is updated annually and among other variables it contains data on: date of birth, gender, route of transmission, race, date of first HIV-1 positive test, bodyweight, immigration and emigration, date of death, date of HAART initiation, HAART regimens and reasons for modifications.
The most common reason for modification was adverse effects of GPOvir® (73.5%), followed by treatment failure (16.7%), for treatment of tuberculosis (TB) (4.2%), and pregnancy (2.7%).
Virological failure was defined as such if the physician treating the patients' HIV infection had stated virological failure as the reason for modification in the medical file.
Another reason for modification may be triggered by the fact that research practice reveals problems in interdisciplinary communication or cooperation which are not considered in the theoretical model but should, nevertheless, be integrated.
Figure 2 shows the Kaplan-Meier estimates of regimen modification by reasons for the modification; lipodystrophy, rash and treatment failure.
After identifying the reasons for regimen modification, Cox's proportional hazard models were fitted in order to identify the factors associated with regimen modification for different reasons.
As we assumed that predictors were different depending on reasons for regimen modification, we fitted Cox's proportional hazard models to elucidate the factors associated with reason-specific regimen modification.
Possible electronic and geometric reasons for the modification of the SFE by substitutional Y atoms are identified and discussed.
The reasons for this modification are unclear.
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criteria for modification
indications for modification
implications for modification
reasons for alteration
reasons for change
reasons for realignment
reasons for order
reasons for departure
factors for modification
reasons for rehabilitation
reasons for variation
reasons for amending
considered for modification
reasons for variance
reasons for changes
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