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Thus, there is a trade off in choosing a threshold that is reasonably stringent but allowing a reasonable number of hits.
In this study, a reasonably stringent cutoff (from 1e−45 to 1e−15) and the function DQer were used to break up all contigs containing 10% Q-clones after each merge.
So a cutoff value of 1e-60 was reasonably stringent and chosen for the initial assembly.
This seemed a reasonably stringent criterion, and we used these 128 probesets for one clustering analysis - experiment #1.
For reasonably stringent parameter settings where the FDR < 1 %, the AF discovery mode reports 3.1 6.8 times more motifs compared to the AB discovery.
Furthermore, reasonably stringent limits were desired given the need to define the exposure risk should pyronaridine be given clinically with narrow therapeutic index CYP2D6 substrates.
Similar(51)
"The quality filter will be pretty stringent.
This is a fairly stringent criterion.
(B) Providers might reasonably suggest more stringent A1C goals (such as <6.5%) for selected individual patients, if this can be achieved without significant hypoglycemia or other adverse effects of treatment.
(B) Because additional analyses from several randomized trials suggest a small but incremental benefit in microvascular outcomes with A1C values closer to normal, providers might reasonably suggest more stringent A1C goals for selected individual patients, if this can be achieved without significant hypoglycemia or other adverse effects of treatment.
It seems appropriate to suggest that 'low exercisers' are insufficiently active, but those who are active, but yet fail to meet these stringent guidelines, might reasonably reject the argument that it is necessary or even feasible to increase their physical activity levels to at least 60 min a day.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com