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Although some of this undoubtedly reflects sound business ventures, like the league's investments in digital media or efforts to expand the game internationally, they have nevertheless had a reasonably large effect on the league's bottom line.
The effect sizes (Cohen's d) calculated for the studies showing significant improvement in the primary clinical outcomes ranged from 0.24 to 0.94, with three studies showing a reasonably large effect size [ 37, 38, 42].
The one-step BLMM and two-step mLASSO methods detected similar sets of QTL given that a large number of individuals were studied and the adaptive shrinkage method of BLMM appeared to allow reasonably large effect estimates in case QTL were significant.
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When the meta-analytic techniques used in the EBCTCG overview were applied to these small trials, however, it became apparent that OA was associated with a reasonably large positive effect on both disease-free survival (DFS) and overall survival (OS) in node-positive and node-negative premenopausal women [ 3- 5].
This assumes that reasonably large main effects are first detected, since mediation effects are partitions of main effects.
The effect size was reasonably large (Cohen, 1988; Monk et al, 2012; Syrjanen & Syrjanen, 2013): the mean effect sizes of depleted hairpins were Epi-A = −0.9098; Mes = −0.7681 and Stem-A = −0.7818, and those of amplified hairpins were Epi-A = 0.8128, Mes = 0.8282 and Stem-A = 0.7486 (Supporting Information Fig 12B; Supporting Information Table 12).
In case of high correlations between the dependent variables, as we found, the power of a multivariate analysis of variance (MANOVA) decreases when the expected effect sizes are reasonably large and consistent in the same direction (Cole et al. 1994).
The ray paths cover a reasonably large part of the outer core (Fig. 6a).
The cut-off values should also be high enough to correspond to a reasonably large window period, in order to smooth the measured effect on an adequately large time interval.
We conclude that with adjustment of a covariate, GMDR performs better than MDR and a sample size of 1000∼2000 is reasonably large for detecting gene-gene interactions in the range of effect size reported by the current literature; whereas larger sample size is required for more subtle interactions with accuracy<0.56.
It is possible to detect the effect of an elevated dose level of natural radiation using a reasonably large number of cells per individual and analyzing many individuals [7].
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