One recent investigation established CPP in adolescent female rats, however at a reasonably high dose; while a second reported dose dependence of nicotine-induced CPP in male but not female rats.
In this case, liposomes should have sufficient time to exit from the site of tumour blood vessel leakage and to accumulate at reasonably high dose levels in the surrounding interstitium.
It's much the same during withdrawal: If you drop from a high dose to a reasonably high dose you won't feel too much at all where withdrawal is concerned.
After enzymatic hydrolysis, a relatively clean sugar stream (both xylose and glucose) could be obtained at reasonably high yield and economically relevant enzyme dose.
These existing data on methyl eugenol are confined to only a few target studies and a reasonably extensive NTP evaluation, albeit at comparatively high doses administered in bolus form.
These patients receive such RIT when lesion uptake in the dosimetry procedure permits reasonably high confidence that the RIT will yield tumour doses exceeding 100 Gy, while staying within established limits for avoiding bone marrow toxicity.
Since, in high doses, rocuronium (ROC) has a reasonably rapid onset and can be reversed with sugammadex, it has the potential to be used in place of succinylcholine [5 8].
It is analogous to the cancer bioassay strategy of using high doses to identify carcinogenic potential in reasonably small samples of rodents.
The model based mTPI, TEQR, BOIN, CRM and EWOC designs perform well and assign the greatest percentages of patients to the MTD, and also have a reasonably high probability of picking the true MTD across the three dose-toxicity curves examined.
At present, we think that the best approach is to maintain a light and comfortable level of sedation, if it is reasonably possible, in order to decrease the incidence of adverse effects of high doses of sedatives.
