We chose this dataset, because (i) it contains a diverse set of gene families from a reasonably large and divergent set of species, and (ii) the parametric bootstrap-like simulation procedure used attempts to retain as much of the complexity of the underlying biological dataset as possible (Szöllősi et al., 2013b).
What keeps Californians reasonably happy across a divergent land of blue-hued coastlines and dusty agricultural acreage, palm trees and Sequoias, mock Med mini-mansions and lookalike stucco ranch homes?
Not surprisingly, the four S. cerevisiae Ssa Hsp70s supported growth reasonably well, although the somewhat more divergent inducible Ssa3p and Ssa4p did not function as well as Ssa1p and Ssa2p.
One might therefore reasonably expect a detailed comparison of the divergent RBD structures to yield a better understanding of the strikingly different roles performed by the corresponding proteins in CRM1-mediated export.
Dehalococcoides ethanogenes has two highly divergent paralogs, but Det_2 can be reasonably excluded from the primary-biosynthesis pathway (and, therefore, from the Det concatenated sequence of Figure 2) because it alone is not located within the whole-pathway operon trpAaAbBDC aroAIβ) EbEa [ 6].
My initial reaction is that the differences in substrate specificity, and the roles of these divergent Cas1 orthologs in conferring that specificity, represent a reasonably significant advance, though this is a somewhat close call.
While the logarithmic length distributions of both the uni-directional and the convergent regions can be approximated reasonably well by a single Gaussian, this is not the case for the divergent regions.
I didn't agree with him, and I am reasonably certain that our views on the results of the war thus far would probably be more than a little divergent as well.
