Sentence examples for reasonable potency from inspiring English sources

But the CDC had been screening drugs in cell culture experiments with a 1976 Ebola isolate and brincidofovir's reasonable potency was announced in October 2014.

Though developed as a potent GSI, LY411,575 also blocks the activity of all human SPP homologues and P. falciparum SPP with reasonable potency [18], [19].

What makes TAK-779 unique among current prototypic antagonists, is that it also has reasonable potency and efficacy at a relatively unrelated chemokine receptor of a different class, namely CXCR3 (Gao et al., 2003; Verzijl et al., 2008).

Numerous compounds, such as compound 4 and the 4-benzyloxybenzoyl derivative compound 5, with small polar P3 residues, in this case a threonine residue, retained reasonable potency in vitro (β5 IC50 values of approx. 500 nM).

This displayed some selectivity towards DAPK1 and reasonable potency, and from the X-ray co-crystal structure we identified the molecular details of the interaction of 6 with DAPK1.

By contrast, introduction of asparagine, which is the residue present at this position in the related long-chain fatty acid receptor FFA1 (26, 26) to generate hFFA2-C4.57G/H6.55N produced a receptor with reasonable potency for compound 25 (Fig. 8 C), while losing nearly all measurable activity to the endogenous SCFA ligands C1 C5 (Fig. 8 D).

In order to identify ATP-site directed scaffolds that possess reasonable selectivity and potency for inhibiting BTK, we queried our historical database of kinase selectivity data generated using a combination of enzymatic binding (KinomeScan) and chemical proteomic (KiNativ) approaches.

For 41 chemicals there exist both reasonable data on carcinogenic potency in experimental animals and also a defined Permissible Exposure Level (PEL), which is the upper limit of legally permissible chronic occupational exposure for U.S. workers.

The inhibitor RO9021 has reasonable kinase selectivity profile, potency and oral bioavailability and is capable of suppressing various innate and adaptive immune responses in vitro, as well as disease progression in the mouse collagen-induced arthritis (mCIA) model.

Within the synthetic antibody panel from which E10 and F4 were discovered (all highly related in terms of sequence), there was reasonable correlation between neutralization potency and binding affinity.

In all cases, the molar concentration at which blockade of an agonist response is first encountered is a reasonable indication of the molecular potency of the antagonist, with the possible exception being allosteric modulators that block receptor signaling but increase the affinity of the receptor for the agonist.