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However, if the data contain heterogeneous transcriptome from a broad range of samples, an alternative would be more reasonable; module genes are assumed to be co-regulated in only a subset of samples.
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At reasonable levels of module resolution, the modules consist mainly of sparsely connected but highly clustered nodes (low k, high C).
Within reasonable assumptions, numerous module equations are combined to yield a 6th-order nonlinear model.
The presence of HIF1A, a hypoxia responsive TF, does seem reasonable in a module that contains many glycolysis genes i.e. an alternative energy conversion pathway used in the absence of enough oxygen availability.
This categorical description encompasses all reasonable definitions of modules; in particular, that of a group representation and that of a module over a Lie algebra.
Considering the reasonable number of modules and connection of nodes in our healthy subjects, we mainly displayed the modules of healthy control, non-HE and MHE groups at sparsity = 8%, where our healthy control group had the same number of modules as that reported by Salvador et al. [ 30].
After aligning a pair of nodes u and v, we then consider aligning their neighbors, which is reasonable because functional modules and protein complexes are densely connected and tend to be separated from other subnetwork modules.
Similarly, values for episode duration and recurrence rates that were used to calibrate the module represent reasonable values given published estimates.
It is intriguing that the gene expression levels are significantly distinct between meta-groups (Dunn's Method, p<0.001), but are often insignificant within meta-groups (data not shown), implying the partition of modules is reasonable.
Packages of power modules are designed to show a slightly convex shape of the base-plate in order to achieve a reasonable thermal contact between the module and the heat sink when the power module is mounted.
Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com