Sentence examples for reasonable in vitro from inspiring English sources

Some of the new compounds (2f, 6a and 6d) showed a reasonable in vitro COX-2 inhibitory activity, with IC50 value of 0.45 μM and selectivity index of 111.1.

Cubosomes loaded with 5-FU exhibited reasonable in vitro characteristics.

In place of whole animal models, cell lines such as human prostate epithelial cells (Achanzar et al. 2002), keratinocytes (Pi et al. 2003), and urothelial cells (Sens et al. 2004), which may represent in vivo targets of arsenic, provide a relevant and reasonable in vitro approach to study the molecular events in inorganic arsenic carcinogenesis.

As another example, the PSD95-PDZ3 domain has selected a set of unusual peptides with the C-terminus W-Y-H-S-F-COOH (see Table S1), with which it interacts selectively and with reasonable affinity in vitro (Fig. 1, peptides # 17, 18, 19 and 20, and not shown).

It would also be reasonable for in vitro experiments where the tissue is placed in a large stirred bath of solution containing the treatment.

A resulting bioluminescent cell line with reasonable bioluminescence in vitro (D3) was isolated and injected into the mammary fat pad of nude mice.

Numerous compounds, such as compound 4 and the 4-benzyloxybenzoyl derivative compound 5, with small polar P3 residues, in this case a threonine residue, retained reasonable potency in vitro (β5 IC50 values of approx. 500 nM).

This factor becomes problematic when attempting to produce biokinetic models or when defining what are reasonable exposures for in vitro studies.

Our hypothesis that HNE modification of Hsp70 or Hsp90 leads to the release and activation of HSF1 is supported by a reasonable body of in vitro and in vivo results.

Since all implantable components are designed for a lifetime of five years to bridge a reasonable timeframe, further in vitro and in vivo studies, especially long term trials, are necessary to confirm the performance of the entire control unit.

BV-2 cells, derived from primary mouse microglia cells, are considered as a reasonable model for in vitro pharmacological studies, since their response to LPS showed a similar pattern to primary microglia in vivo based on transcriptome and proteome analysis [ 26].