However, we would suggest that the relevant question moving forward is this: "Is it reasonable to expect that an immune response elicited against a single HSV-2 protein should render the body completely resistant to infection with an actual HSV-2 virus?" Viruses are highly evolved genetic elements whose complexity exceeds the sum of their proteins.
Thus, although, on average, the HI test is a reasonable surrogate for the human immune response, there might be cases when this test misses epidemiologically relevant serological differences between influenza isolates.
Consistent with the innate immune system evolving prior to the adaptive immune response, it is reasonable to assume that molecules involved in this system may have evolved more rapidly and be genetically conserved across a broad spectrum of evolutionary distant species.
It is thus reasonable to speculate that the lymphocyte-mediated immune response against damaged tumor cells is critically important for achieving CR after RT in patients with RC.
Therefore, a reasonable method to monitor the evolving lymph node (LN) immune response is assessment of LN metabolic activity using standardized uptake value (SUV) as a simple semiquantitative measure of 18F-FDG uptake [3],[4].
Such age-related changes of the immune response are multifactorial, but it is reasonable to think that the extra-cellular milieu is very important.
With this in mind, it is reasonable to hypothesise that the impact of Tregs on the immune response to tumours developing in vivo may differ to their impact on the immune response to tumour cell lines.
It is reasonable to suppose that the more differentiated networks reflect an immune response, while the less connected networks reflect a more stable state.
The use of commercial N. atra antivenom in treatment of snakebites caused by N. kaouthia is reasonable, but design of novel antivenom with the attention on enhancing the immune response of non-immunocaptured components should be encouraged.
It is reasonable to assume that with the variety of genes and processes that comprise the immune response that the stimulation of this response seen in exposed worms includes a combination, if not all, of these processes.
