"Inhalation anthrax," Dr. Koplan said, "requires both aerosolization and some reasonable dose of spores, thought to be many thousand".
But the piece broadly seems to conclude that the path to higher fertility rates (interestingly, not all experts quoted believe this is necessary for societies to thrive) is put down to a handful of factors: either generosity (as in Scandinavian social programmes) or flexibility (as in American-style working conditions), combined with a reasonable dose of fatherly nappy-changing.
This should not occur until the treating physician has reassessed fluid resuscitation status and a reasonable dose of catecholamine has been given an opportunity to increase the blood pressure (suggested ≥0.5 µg/kg/min of noradrenaline or equivalent).
Naringenin is bioavailable after reasonable doses; for example, a dose of 139-265 mg naringenin yielded 0.7-14.8 μM of the aglycone in the blood after absorption (Erlund et al., 2001).
The design of the PPTF and the HCB walls adjacent to the PPTF aims to have the docking room, which is next to the test tank room containing the PPTF, having as low as reasonable dose rate of 25 μSv/h.
Nevertheless, the discordance of data in the literature might indicate that glucocorticoids at least do not carry a very high risk of malignancy and that they might be relatively safe regarding solid organ tumors, especially if used in reasonable doses and for limited periods of time.
The side effects for I-based therapies in humans are generally mild when administered in reasonable doses [ 40, 41] and the safety of MV-NIS has been vetted in preclinical toxicity studies and phase I clinical trials [ 42- 44].
Calciferol does not appear to be toxic at reasonable doses.
In the MAC-6 study [ 16], the 5 days on/2 days off administration of capecitabine was introduced to ensure the absence of a completely drug-free interval during treatment, while maintaining a reasonable dose intensity, and a rate of grade 3 diarrhea of 8.1% was obtained.
After 3 centuries of reasonable dosing based originally upon the Schedula Romana, treatment recommendations for quinine in severe malaria were suddenly reduced in the 1970s to a dose as low as 5 mg/kg/24 h, which is eight times lower than that now recommended.
