In reasonable doses and proper circumstances, Laphroaig can be delicious, but its popularity is a mixed blessing for the industry, because whisky neophytes who try Laphroaig and hate it may never return.
"In reasonable doses, and assuming good quality control, nicotine might raise your heart rate two or three beats per minute, but it really has few adverse effects".
Nevertheless, the discordance of data in the literature might indicate that glucocorticoids at least do not carry a very high risk of malignancy and that they might be relatively safe regarding solid organ tumors, especially if used in reasonable doses and for limited periods of time.
In the MAC-6 study [ 16], the 5 days on/2 days off administration of capecitabine was introduced to ensure the absence of a completely drug-free interval during treatment, while maintaining a reasonable dose intensity, and a rate of grade 3 diarrhea of 8.1% was obtained.
"Inhalation anthrax," Dr. Koplan said, "requires both aerosolization and some reasonable dose of spores, thought to be many thousand".
40-second acquisition time could be an optimal compromise to obtain an accurate measurement of the PS and a reasonable dose exposure with a deconvolution method.
This should not occur until the treating physician has reassessed fluid resuscitation status and a reasonable dose of catecholamine has been given an opportunity to increase the blood pressure (suggested ≥0.5 µg/kg/min of noradrenaline or equivalent).
You could take a benzodiazepine and go to an important meeting, and at a reasonable dose, you'd likely be fine.
In October 2006, an effort was made to improve the practice of dose rounding; indeed, all staff members were provided with a leaflet indicating the most reasonable dose rounding depending on body surface/weight and available vial sizes.
