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A reasonable cut-off could be set at 50%, as shown in figure 1.
For each model, estimates of specificity and positive and negative likelihood ratios (LR) were obtained given a baseline sensitivity of 85%, which has precedence in the literature as a reasonable cut-off level for biomarker comparison of Alzheimer's disease (AD) [38], [39].
The value of 96% seems a reasonable cut-off value.
Again this was a reasonable cut-off for anxiety and depression subscales.
In the global context, 70 years might be a more reasonable cut-off (40).
This was also a reasonable cut-off for HADS-A and HADS-D.
Hence, 40% inhibition served as a reasonable cut-off below which only minor efficacy has to be expected.
A reasonable cut-off value was 215 pg/mL, resulting in an OR of 3.8 (95% CI 2.2 6.7).
The coarseness of the possible selections creates a problem for finding a reasonable cut-off p-value.
We chose 3 years as a reasonable cut-off time since the great majority of colon cancer cases (91%) have a recurrence within this time frame.
Despite the statistically reasonable cut-off of p-value and the 100%-correct prediction criteria, we found that a large proportion of the lung cancer gene markers reported in the literature were still filtered out (Methods).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com