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Lastly, we could not clarify the precise reason for progression to ESRD among patients with initially benign clinical presentations.
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The major reason for disease progression was distant failure but not local recurrence.
The high frequency of local relapse and of distant metastasis is the main reason for tumour progression.
One reason for this progression is that the effect of other factors on outcomes is likely to increase along the pathway.
If changes of peripheral refraction are the primary reason for slowing progression of myopia, this would be expected to decrease axial length elongation especially in high myopia patients [ 36].
29 In the current framework, we did not specifically model other reasons for disease progression, although implicitly other reasons for disease progression were at least partially captured by the dropout model.
Annual or bi-annual national estimates of rates of OI diagnoses will be the gold standard for measuring the effectiveness of reducing the severity of HIV-related disease, for describing the characteristics of persons who have progressive HIV disease, and for characterizing the reasons for disease progression.
Therefore by investigating this phenemoenom in aged Biozzi-ABH mice we might be able to elucidate some reasons for the progression of MS in people.
Reasons for tumor progression could be related to transient immunodepression, reduced efficacy of the immune system response with aging and tumor cell acquisition of the capability to exploit immunological mechanisms and evade immune surveillance [ 13- 15].
One of the main reasons for disease progression in apparently radically resected gastric cancer patients is represented by the frequent occurrence of locoregional relapse (Macdonald et al, 2001; Gunderson, 2002; Park et al, 2003).
However, a few clinical studies have examined the use of Bev as a single agent in metastatic CRC, and the one study conducted with single-agent Bev in such patients did not specifically investigate sites of metastasis or reasons for disease progression (Giantonio et al, 2007).
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