Sentence examples for rearranged segments from inspiring English sources
Deletional rearrangement detection, conversely, requires sequencing rearranged segments adjacent to a captured RSS not participating in the rearrangement.
To specify the impact of rearrangement, the replication efficiencies of human RV with rearranged segments 7, 11 or both were compared to these of the homologous human wild-type RV (wt-RV) and of the bovine wt-RV strain RF.
Furthermore, it has been proposed that there should be a move towards visualizing genomic rearrangements, such as gene fusions, graphically to emphasize the order of the rearranged segments rather than the genomic distance between the breakpoints [ 30].
However, the reasons why rearranged segments are preferentially packaged into RV remain to be determined.
We thus consider the number of passages required for the expansion of rearranged segments in the viral progeny as a direct indicator of the packaging efficiency rate of rearranged segments.
Taken together, lack of growth advantage conferred by rearranged segments to r-RV, combined with the constant selection of rearranged segments in viral progenies, strongly suggests a preferential segregation of rearranged segments rather than an overgrow of r-RV over wt-RV during viral replication.
Virus M0 has 11 standard dsRNA segments, virus M1 has a rearranged segment 7, termed 7R, virus M2 harbors the rearranged segment 7R and a rearranged segment 11, termed 11R, virus M3 has a rearranged segment 7, termed 7RΔ and virus M4 harbors the rearranged segment 11R (see figure 1 for details).
Virus M0 has 11 standard dsRNA segments, virus M1 has a rearranged segment 7, termed 7R (Genbank AF338247), virus M2 harbors the rearranged segment 7R and a rearranged segment 11, termed 11R (Genbank AF338245), and virus M3 a rearranged segment 7, termed 7RΔ (Genbank AF338248) (see figure 1 for details).
Paradoxically, if rearranged RNA segments have a selective advantage in packaging, why all RV do not possess rearranged segment(s)?
Similar results were obtained from competitive experiments between wt-RV M0 and r-RV carrying the rearranged segment 11R.
Prior studies have reported similar results for bovine or porcine RV carrying rearranged segment(s) [11], [19], [30], [31].
