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Discover LudwigThe phrase "really major" is correct and commonly used in written English.
It can be used to describe something significant or important in a sentence. Example: "The discovery of penicillin was a really major breakthrough in the field of medicine."
Exact(58)
But he fucked up something really major.
Bovine tuberculosis is a really major disease.
It was nothing really major.
No, really, major life disruption.
Therein lies a really major opportunity for a Republican administration.
"We're wanting to have a really major impact on disease.
Twenty-five paintings make up the exhibit, and at least a dozen are really major performances.
The last one that was really major was the 1861-62 flood.
"We cut hair for really major events — so birth, death, weddings," Bell says.
Similar(2)
That, to employ Bussell's favourite superlative, would be 'really major'.
The result is that many people get the label Major Depressive Disorder, even though their presentation isn't really 'Major', isn't really 'Depressive', isn't really 'Disorder'.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com