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Indeed, the fibroblast contribution to tumor progression through paracrine signalling is, in turn, attributable to the cancer cell ability in altering fibroblast nature, realizing a sort of genome reprogramming of these stromal cells that are 'instructed' to secrete pro-tumorigenic soluble factors (Stuelten et al, 2010; Tyan et al, 2011).
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They were, I realized, a sort of low-cost spa treatment.
Halfway from the corner he wanted, Mr. Beresford realized with a sort of sick shock that the man in the light hat was at his elbow, walking steadily along next to him.
It's a cheerful, familial moment realized as a sort of theatre of ordinariness that exalts the simple pleasures of a life in safety as an elusive paradise, one that's brutally threatened by the hands-on violence concealed in France's administrative indifference.
You don't realize what a sort of selfish existence you live in until you have kids".
In Aristotle's view an item in nature persists by the active exercise of a collection of capacities, a self-maintaing internal process organization (physis, or more generally morphē) that realizes a characteristic sort of functioning; by means of these characteristic types of functioning we sort entities into natural kinds.
"We realized there was a sort of self-reflexive story in there about a kid who wanted to be an artist and was trying to preserve something that's quite difficult in difficult times, so we sort of felt, O.K., that kind of mirrors what we're trying to do" with the hand-drawn animation, Mr. Moore said.
But, once people "sat up and took notice" about the kind of material Charlie publishes, Rauhala said, she thinks they realized it's "a sort of notably juvenile publication".
Mr. Wasserstein said he was realizing a dream of sorts.
"They arrive there and realize that it's a sort of an improvised show," Mr. Deprit said.
What does it mean for you that the "Shrek" series is coming to an end? A. I realized it's been a sort of safety net.
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