Despite the great promise of PTT in cancer treatment using nanomaterials, the development of a new generation of PTT agents with enhanced NIR absorption and multiple functions to realize imaging-guided highly effective cancer therapy still merits further effort.
With this system, we have successfully realized imaging at the single-photon level with a single-pixel avalanche photodiode without point-by-point raster scanning.
Furthermore, owing to the remarkable biocompatibility of polydopamine (PDA), the SERS nanoprobe can be smoothly internalized into cancer cells to realize SERS imaging in Raman-silent region.
While all the above media have specific domains of application, hyperbolic metamaterials are a multi-functional platform to realize waveguiding, imaging, sensing, quantum and thermal engineering beyond conventional devices [13 18].
Secondly, to realize ultrahigh imaging speed, the SD-OCT systems usually use a linear sensor array with limited number of pixels, resulting in a significantly reduced imaging range (~3.0 mm in air) and rapid sensitivity fall-off (~6 dB/1.5 mm) [ 35, 38].
Through precisely controlling the recording and reading time periods of the two cameras, the SDOCT system realizes an imaging speed at 500,000 A-lines per second, while maintaining both high axial resolution (~8 μm) and acceptable depth ranging (~2.5 mm).
The essence to construct multimodal imaging nanoprobes is to utilize the paramagnetic properties of Gd3+, Fe3O4, TaO x to realize MRI imaging, the high attenuation of X-ray of lanthanide ions (e.g., Lu3+ or Yb3+) to realize CT imaging, the Yb3+, Er3+/Tm3+ lanthanide elements to realize the UC PL, and the radionuclide Sm for SPECT imaging or the F radionuclide for PET imaging.
Thus, their residence time will increase, which may realize steady imaging.
The asymmetric design may be effective to realize an imaging spectrometer.
Then under one certain polarization condition, either one of permittivity and permeability negative is sufficient to realize perfect imaging.
