Indeed, one emerging observation in both extracellular signal- regulated kinase 1 and 2 (ERK1/2) and mammalian target of rapamycin (mTOR) signaling is the realization that pathways generate specific biological responses dependent upon where in the cell the signal originates [ 12].
Over the past few years, there has been a growing realization that metabolic pathways must be studied in the context of the whole cell rather than at the single pathway level, and that even the simplest modifications can send ripples throughout the entire system.
Back to the realization that the pathways forward all flow from that which is best in the human spirit: our thirst for useful knowledge, our compassion for our fellow beings, and our belief in their essential dignity.
The realization of such pathways will allow a significant portion of today's energy infrastructure to play an important role in the evolution of global energy systems, which is critical to avoiding stranded costs and addressing the scale requirements of meeting future energy demands.
This core shell CNT Ni Si nanostructure provides a simple but effective pathway towards realization of long lifetime and high performance lithium ion batteries.
The philosophy of drug repositioning is underpinned by the emerging realization that common molecular pathways are often shared among seemingly diverse diseases.
Ultrathin silicon provides a viable pathway towards the realization of photovoltaic devices aimed at reducing material usage, utilizing low quality material and diversifying their application.
The net result is the realization of the concept of pathway pathology through analysis of a large cohort of whole slide images.
The ST configuration is an alternate magnetic confinement concept which is characterized by high β (ratio plasma pressure to magnetic field pressure) and low toroidal field compared to conventional tokamaks, and could provide a pathway to the realization of a practical fusion power source.
Biochemical, genetic and physiological investigations of chemotaxis-like signaling pathways in bacteria other than E. coli have led to the realization that some of these pathways carry out functions distinct from the well-established role in regulating flagellar motor rotation.
Attention is returning to these other pathways with the realization that their influence may have been underappreciated because supraphysiological [Ca2+]o employed in most studies ensured maximal receptor activation and decreased the impact of physiological decreases in external [Ca2+].
