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We emphasize the incorporation of PD assessment into early clinical trial design, providing a breakdown of PD biomarker data that can be realistically obtained at each trial phase and a framework for constructing clinical protocols to include PD biomarker studies.
Pooling data from multiple studies can provide an alternative source of evidence that can be realistically obtained in a cost-efficient way.
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We employ a collection of MCMC techniques (see 'Materials and methods'), but while different initializations converge to similar ultimate values, we can never realistically obtain the global optimum.
Realistically, obtaining assent is seldom possible in the critical care environment but whenever possible, assent should be taken in a developmentally appropriate manner [ 22] and may require alternative communication methods in ventilated children, for example.
A volume of 6 mL was chosen, as this is a volume that can realistically be obtained in clinical trials without exceeding the possible total amount of blood that can be drawn in the context of other measurements.
Although a proper estimate of seal resistance cannot realistically be obtained in RBCs (it would require simultaneous patching with two pipettes), this has been done in larger cells and found to vary widely over a range situated below 50 GΩ [42].
ii) The exposure period of relevance is before the date at which measurements can realistically be obtained and of unknown duration and induction period.
It is shown that fatigue-driven residual strength can be obtained realistically from experimental data using the new formulae.
One of the basic design decisions was to aim at high-quality schedules for realistically sized problems obtained rather quickly, while maintaining human control.
The operation and energy consumption of the system operating either with the new control system or with the traditional on off control were compared to realistically quantify the obtained gains.
When the Peierls model is extended to two dimensions the resulting line energy, line tension and resistance against bow-outs of straight dislocations can be obtained realistically without any adjustable parameters and the way that these quantities are influenced by the interplanar atomic potential can be studied.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com