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Initially, the data underwent rigid body realignment to correct for head movement using rigid body motion correction procedure (Friston et al. 1996).
This consisted of realignment to correct for motion effects and minimal spatial smoothing with a 3 mm FWHM Gaussian kernel.
The subsequent local realignment to correct misalignments due to the presence of indels was performed using the Genome Analysis Toolkit (GATK) [ 51] with the IndelRealigner function.
Image preprocessing involved realignment to correct for head motion between scans, normalization into standard Montreal Neurological Institute (MNI) stereotactic brain space, and smoothing with an isotropic 10 mm full-width-at-half-maximum Gaussian kernel.
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Then the 5 echoes of the remaining images were realigned to correct for motion artifacts (estimation of the realignment parameters is done for one echo and then copied to the other echoes).
Data were temporally realigned to correct for interleaved slice acquisition and spatially realigned to correct for head motion using FSL's MCFLIRT linear realignment tool.
Genome analysis toolkit 1.4 (GATK) (Nekrutenko and Taylor 2012) was used to perform local realignment of reads to correct misalignments due to the presence of indels ("RealignerTargetCreator" and "IndelRealigner" arguments).
Realignment osteotomy aims to correct limb alignment and may influence knee osteoarthritis [6].
Therefore, the aim of this investigation was to examine the impact of four different realignment methods designed to correct acceleration signals on a range of upper body variables in older adults and in patients with PD.
The local realignment step aims to correct misalignment caused by the presence of insertions or deletions (indels).
This analysis included standard preprocessing procedures: realignment, slice timing to correct for differences in slice acquisition time, normalization (images were normalized to an EPI template), and smoothing (with an isotropic 8-mm FWHM Gaussian kernel).
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CEO of Professional Science Editing for Scientists @ prosciediting.com