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Currently, there are limited "real-world" exposure data.
While many of these approaches are conducted under rigorous laboratory conditions, a significant challenge has been the interpretation of omics data in "real-world" exposure scenarios.
However research on the cardiovascular effect of "real-world" exposure to ambient particulate matter (PM) in susceptible animal model is very limited.
He studied political science but craved a real-world exposure to campaigns that led him to bolt in his senior year for a career as a political gym rat.
Still, in a beta test — the last stage of testing, aimed at product debugging and real-world exposure — the site already has a number of blue-chip advertisers, including State Farm Insurance and the automaker Nissan, which is promoting its Quest minivan.
In a letter to the E.P.A. administrator, Andrew Wheeler, the committee's chairman, Louis Anthony Cox Jr., said the agency had not provided "a sufficiently comprehensive, systematic assessment of the available science". This is despite the fact that epidemiological studies from around the world have shown a robust association between real-world exposure to PM 2.5 and premature mortality.
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Applying a variety of different nanoparticle treatments in this slow, chronic fashion allows researchers to simulate real-world exposures and illuminate any potential differences between classes of nanomaterials.
Vallero, D; Isukapalli, S, Simulating real-world exposures during emergency events: Studying effects of indoor and outdoor releases in the Urban Dispersion Program in upper Manhattan, NY, Journal of Exposure Science & Environmental Epidemiology, vol 24 no. 3 (2014), pp. 279-289 [abs1038/jes.2013.38] [abs].
Vallero, D; Isukapalli, S, Simulating real-world exposures during emergency events: studying effects of indoor and outdoor releases in the Urban Dispersion Program in upper Manhattan, NY., Journal of Exposure Science & Environmental Epidemiology, vol 24 no. 3 (2014), pp. 279-289 [abs1038/jes.2013.38] [abs].
However, estimates of toxicokinetics are necessary to extrapolate in vitro conditions (e.g., bioactive concentrations assessed in ToxCast assay) to the predicted real-world exposures (e.g., mg/kg bodyweight/day) that might correspond to those bioactive concentrations in tissues of humans or test animals [89].
The use of NTA is increasingly being employed in environmental research to gather information on the real-world exposures to a broad range of chemicals potentially present in media such as wastewater [138], water [124, 139], dust [123], sediment and others.
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