But the researchers maintain their methods and findings are valid and reflect possible effects at real-world concentrations.
It can be argued that, because induction of adverse effects in such models only occurs at levels of exposure considerably greater than those experienced by humans, effects at real-world concentrations of the chemical in question are unlikely to occur.
Hydrocarbons were shown to induce persisting changes in protein expression and neurotransmitter levels in the central nervous system and to impair neurobehavioral function in rats at the "real-world" concentrations experienced by human beings (Ritchie et al. 2001b).
These results, based on a large human population and using real-world concentrations of PM components, provide a much more complete picture of the health effects of PM chemical components than previously available.
In addition, most traditional toxicological tests use doses 1,000 1,000,000 times that of the equivalent physiological range at which the endocrine systems operate and well above real-world exposure concentrations to synthetic chemicals.
10 To date, no study has described the real world relation between community plasma HIV RNA concentrations and HIV incidence.
Just concentrate on the real world.
A well-known limitation of in vitro studies is the general use of exposure concentrations that are on the high side, compared to real world situations.
Back in the real world, the competition grows between Roxie and Velma (Catherine Zeta-Jones) for the public's attention and constantly diminishing concentration.
