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To tell apart real alignment from statistical effects, we need to compare the results obtained on the real data with a suitable null model [40].
If X-rays are positive, the patient should get supine full-length anteroposterior (A-P) X-rays of both legs to evaluate the real alignment.
"If there's a real alignment of a sponsor section on a particular topic, we find the best content in the world on that topic and draw attention to it better than anyone else can, and it's great for our partner in those cases.
To better reflect the real alignment problems of interest, simulated reads are derived from the human genome (NCBI Build 36.1), rather than constructing an artificial random genome to permit the assessment of the sensitivity and accuracy of alignment of short reads that contain variants including errors, single base mismatches, insertions, and deletions as well as combinations.
Table 3 indicates the gappyness of the alignments used (not counting real alignment gaps).
The random databases were analyzed in the same all-against-all fashion, and the resulting scores were compared against real alignment scores.
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(2013b), but focusing on real alignments.
All tree topologies used in reconstruction tests were inferred from real alignments.
All tree topologies are generated from real alignments and the distances are rescaled in order to make the trees comparable.
All of the simulated and real alignments mentioned in the paper are available for download from [ 58].
Because the lengths of the real and simulated alignments differed, the positions and lengths of the gaps in the real alignments were scaled to the length of the simulated alignments (i.e., longer alignments have longer gaps than shorter alignments).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com