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However, for treatment of disseminated massive sulfide ores, a much more complex reagent scheme is used.
The reagent scheme used in the treatment of lead zinc ores varies considerably and depends on the nature and mineralogy of the ore.
Based on the interesting findings, it is suggested that the design of an optimum dewatering reagent scheme need not be based on short duration sedimentation and/or filtration trials alone.
The bifunctional chelator NODIA-Me 1 bearing an acetic acid residue for the covalent attachment of appropriate targeting vectors was successfully conjugated to the peptide c RGDfK) 2 in DMF using HATU as coupling reagent (Scheme 1).
In 2014, Gade and co-workers reported the highly enantioselective Cu-catalyzed trifluoromethylthiolation of β-ketoesters by using 366 as SCF3-transfer reagent (Scheme 141).
In contrast, the coupling of alkyl-substituted Grignard 13 proceeded in 93% ee when excess organomagnesium reagent was employed, but the ee fell precipitously when Grignard 13 was used as the limiting reagent (Scheme 2 b).
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These reagent schemes are normally employed for treatment of carbonatite and coarse-grained massive sulfides.
The type of reagent schemes also varies by regions, where the application of new technology (i.e., new collectors and depressants) in some regions is very slow and the operating plants rely on the old conventional processes and technology.
Bauer and co-workers reported the use of XAS to study the mechanism of reaction between aryl halides and Grignard reagents (Scheme 3) [17].
A novel synthetic procedure was successfully demonstrated to generate laboratory-scale lesinurad in six steps and a 38.8% overall yield, without using extremely poisonous organic reagents (Scheme 5).
In 2009, Carretero and co-workers reported a Pd-catalyzed cross-coupling between enantioenriched secondary benzylic bromides and aryl or vinyl Grignard reagents (Scheme 19 ).
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