Sentence examples for reads to highly from inspiring English sources

SHRiMP is a package for mapping short reads to highly polymorphic genomes with a statistical method for scoring the alignment [ 4].

The iterative remapping stage uses successively identified high confidence variant sequences as additional reference allele fragments to enhance alignment of reads to highly mutated regions of the genome.

Break points with many differences from the reference sequence may be at a coverage that is less than the genome average due to the difficulty of aligning reads to highly polymorphic areas of the genome.

While some of the unresolved sequence is certainly a consequence of strain-specific VR deletions or duplications, the majority is likely due to the challenge of uniquely mapping short sequence reads to highly repetitive genes [ 50].

However, this performance drop is mainly due to the difficulty of aligning short reads to a highly diverged reference.

HGAP [ 16] relies on shorter single-molecule sequencing reads to construct highly accurate preassemblies on single-molecule sequencing reads that are longer than the seed length.

These noncanonical sites could be derived mostly from mis-mapping reads to a highly similar genomic duplicate region, as suggested by Piskol et al. [ 31].

Strict parameters were used (0 mismatches and no gaps) for mapping G186A reads to generate a highly accurate alignment result.

We excluded the CB4858 datasets due to the inherent inability of short reads to represent loci with highly clustered polymorphisms.

Any available mapping algorithm will suffice to map highly identical reads to a reference.

Despite this interest, the use of NGS data for HLA loci is hampered by a major technical hurdle, which is the mapping of short sequence reads to genes that are both highly polymorphic and which constitute a multigene family.