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The importance of TRAIL suggests that TRAIL production by T cells or NK cells could be an important readout to predict the efficacy of cancer vaccines or immunotherapies, possibly equally important as perforin-mediated cell apoptosis and IFN-γ.
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Such changes occurring in DCs have been employed as assay readouts to predict skin-sensitizing potentials of small chemicals.
A state-of-the-art sequence-to-expression model, GEMSTAT (He et al. 2010), was used to predict the expression readouts of the hairy and sog CRMs.
The model used to predict the sog CRM readout was trained on the Drosophila ind and sog (shadow) enhancers (Stathopoulos and Levine 2005; Hong et al. 2008).
Because light scattering gives a dynamic readout of the nanosheet growth, we sought to predict nanosheet size over the range of solution conditions examined above and develop a mechanism for self-assembly.
Their study showed that FMT provides more sensitive readouts in the pathology of the disease and that it is possible to use FMT results to predict disease development [ 30].
This will involve the powerful combination of alignment-free methods to predict putative homologs in the orthologous gene locus and experimental methods to characterize the expression readout of the predicted homolog.
It became, therefore, straightforward to predict the recombinase enzymatic activity at any time without the need to wait for the morphological/physiological readout of the treated cells.
"We tried to predict.
How? Hard to predict.
With the constant readouts providing more detailed data, Snyder's group saw not only that glucose dysregulation is more common than previously thought, but they also used the data to start building a machine-learning model to predict the specific foods to which people spike.
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