Our interest in comparative population genetics prompted us to characterize the theoretical and practical impact of SNPs on the methylation readouts and on the interpretation of population data.
These studies have generally used lifespan of population cohorts as a primary readout.
However, we demonstrate that IL-2 accumulation by T cells scales as a power law with antigen quantity, independently of population size, providing a shared quantitative readout of the global antigen load.
DESIGN: Fourteen antiretroviral-naive HIV-1-infected patients were identified as having population coreceptor tropism readout of dual/mixed-tropic viruses.
We make the assumption that a decrease in the speed or size of the mobile population provides a readout of increased binding interactions.
A third limitation refers to the importance of the SOFA score as a readout of systemic organ failure in our population, since thrombocytopenia was the only category in which 61% of our patients scored, most of them with high scores.
Gli1 acts exclusively as an activator of transcription and, although not essential for mouse development or Hh signaling, is itself a Hh target gene, so measurement of its transcription can be used as a readout of Hh signaling in a given population of cells.
We reasoned that the readout of long-term, context-independent priors should not depend on specific patterns of population activity driven by higher-level inferences.
PCNA was included as a readout of the proliferative capacity of the different populations and showed a marked decrease consistent with growth arrest at day 7 in the RasV12-transduced population.
Of course, data in biology are inherently noisier because of intrinsic variability in the human patient population and the limited accessibility and readout of specific experiments.
