Exact(3)
MCAK mutants in which the Aurora B phosphorylation sites have been mutated to phospho-mimicking residues no longer bind to MT plus-ends in interphase (Honnappa et al. 2009; Moore et al. 2005), suggesting that MT plus-end localization of MCAK could be a good readout of local Aurora B activity.
Whereas methylation at pattern 2 DMRs may represent a more permanent inactivation with subsequent heterochromatinization of developmental gene loci, pattern 3 DMR methylation may serve as a dynamic readout of local transcriptional activity.
This result is therefore consistent with our suggestion that bAPs can provide a readout of local extrasynaptic glutamate rises, be it from synaptic activity (Rusakov and Kullmann, 1998; Zheng et al., 2008), or through astrocytic (Jabaudon et al., 1999) or ectopic dendritic (Duguid et al., 2007; Shin et al., 2008) release.
Similar(57)
Alternatively, expression of different sets of HOX-genes may reflect a positional identity as differential HOX-gene expression within the genitourinary system has been described previously [ 59, 60], or be a readout of the local balance of developmental morphogen signaling.
Thus, both shaft and spine NMDARs can also sense extracellular glutamate that is transiently elevated as a result of local synaptic activity but require a readout signal, such as the bAP, to be activated.
Luminescence-based readout allowed for early visualisation of the locally overgrown mammary tissue and for longitudinal evaluation of local progression of the tumours.
For the readout, a local front-end with 64-channel Analog Pipeline Chips (APC) has been employed.
Every pMHC TCR complex over the entire cell is tracked while simultaneously monitoring the local membrane recruitment of ZAP70, as a readout of TCR triggering.
Patel, D. J. & Wang, Z. Readout of epigenetic modifications.
"The complete readout of a person's DNA will fit on a CD-ROM".
Just seeing a readout of their vitals at various intervals could help, Dr. Singer said.
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