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Finally, we compute the predicted psychophysical performance by decoding data from real MSTd neurons using each readout model, and we compare the results to animals' behavioral performance.
In contrast, CPs of opposite cells in the selective readout model have a unimodal distribution centered around 0.5 (puni>0.05, modality test, right column in Figure 5D), which is similar to that seen for MSTd neurons (puni>0.05, modality test, left column in Figure 5D).
Although both models also show a similar dependency of CP on neuronal sensitivity in the combined condition (p<<0.001, linear regression, Figure 5F,G), the strength of the correlation is significantly weaker for the pure correlation model (R = −0.41, 95% CI: [−0.32 to −0.48]) than for the selective readout model (R = −0.67, 95% CI: [−0.61 to −0.72], Figure 5H).
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Other important improvements include better electronic readout, better modelling and simulation, and better computational techniques for reconstructing the information carried by the photons.
We think this represents the best combination of a biologically relevant outcome and an experimentally accessible readout for each model.
Ime2 is used as the model readout for sporulation phenotypes because it is the most downstream protein that reflects changes in all others in the pathway.
Computer-based solutions from clinical interventions (e.g., oral glucose tolerance tests with "minimal model" readout) have limitations because of the high number of samples required from each subject.
Noise was added on pixels S ¯ (i, j ) as constant noise S ¯ N of rms value σS = 0.3 (e.g. readout noise, the model pixel values are here assimilated to reflectivities 0 < S ¯ (i, j ) < 1).
Finally, the authors consistently refer to neuropathic model readouts as pain.
The readouts of the model are the amounts of the different phosphorylation and complex states of the proteins involved.
Model readouts included animal survival and clinical signs, cyto-/chemokines profiling, MMP levels, apoptosis, BBB breakdown, and intracerebral haemorrhages.
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