Sentence examples for readout for changes from inspiring English sources

PKA is a major effector protein of cAMP and, hence, monitoring PKA-dependent phosphotransfer reactions serves as surrogate readout for changes in cAMP levels.

This assay probes the ratio of ERp57 molecules with active-site cysteines in the oxidized and reduced state, respectively, and has been used routinely in the field as readout for changes in the ER redox environment [ 23, 27, 43].

It is possible that the higher levels of retrotransposon RNA that we found in the weaker alleles may be due to decreased SPN-E protein levels and that retrotransposon silencing is a more sensitive readout for changes in SPN-E function than the developmental phenotypes that we examined.

In particular, the 25% reduction in local curvature of clonal boundaries separating FasIII-expressing from non-expressing regions represents both a readout for changed intercellular adhesion and a demonstration of how changes in adhesion can sculpt these clonally related cell populations.

We used rCBV as surrogate haemodynamic readout for underlying changes in brain activity [25], [26].

In sum, rhythmicity was selected as the readout for neurodegeneration-associated changes since although its normal age related decline is subtle, impairment of this neuronal circuit has a robust impact on this behavior [23].

It is therefore suggested that the authors should consider measurement of Gli3 processing as a functional readout for PKA activity change under conditions of eliminating Sema3/Nrp1 contributions both with and without Shh stimulation.

This correlates with previous observations that synaptic drive also increases during this period of larval development, although we do not yet have a physiological readout for the specific anatomical changes we detailed in this study.

We chose the liver as a readout as it is the best-characterized organ for changes in autophagic activity and also has a significant physiological role in adaptation to starvation (36).

Our studies also open the door to using changes in metabolite diversity as readout for cumulative damage in age-related studies, and further improvement in sensitivity of this technology should increase the fraction of damage over functional metabolites.

Ime2 is used as the model readout for sporulation phenotypes because it is the most downstream protein that reflects changes in all others in the pathway.