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Other important improvements include better electronic readout, better modelling and simulation, and better computational techniques for reconstructing the information carried by the photons.
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Digital readouts have the advantage of exactness, while analogue readouts give better indications of rates of change.
"We could get a much better readout on chronic safety and efficacy early," said Bart Henderson, the president of Rhythm, which now plans to move into human testing.
The arrays are chemically and biochemically robust; they are spatially addressable and have the potential for being informationally addressable; and they appear to offer better readout capabilities than the classical microarrays.
The additional power dissipation for the readout electronics requires better thermal design, since much of the on-detector infrastructure (front-end electronics crates, cooling pipes, optical fiber plant, etc).
Thus, RNAPII occupancy appears to give a better readout of pri-miRNA transcription.
However, ERE transcriptional activity remains a better readout of ER function as PgR is just one many ER target genes and is regulated by many other transcription factors such as Sp1 or AP-1 [ 28, 29].
De novo labelling as used here determines the outcome of all these processes and, therefore is a better readout of protein synthesis than ribosome loading eventually combined with ribosome footprinting [ 48].
The results show that the binary concept is at least comparable to any analog readout strategy if not better in terms of occupancy.
To evaluate whether the strong synergy between CpG and ISCOMATRIX seen in immunological readouts would translate to better functionality, we also evaluated the CpG/ISCOMATRIX combination in a therapeutic metastatic lung carcinoma model.
That said, I like the readout in the Canon viewfinder better; it seems to me to be brighter and more readable.
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