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A cross-analysis of a rationally designed panel of RNA binding and ATPase mutants and truncated receptors, using type I IFN promoter activation as readout, allows us to refine our understanding of the structure-function relationships of RIG-I and MDA5.
We propose several coding schemes and applications: (1) coded readout allows us to better sample time dimension for high-speed photography and optical flow based applications, including motion interpolation, skew compensation, and motion deblur; and (2) row-wise control enables capturing motion-blur free high dynamic range images from a single shot.
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The AERD data-driven readout architecture operates the address encoding and reset decoding based on an arbitration tree, and allows us to readout only the hit pixels.
In contrast, optical readout of the ionic current allows us to trace every change in the electrical current to a specific pore.
This HSR readout in our zebrafish model allows us to track the axons of stressed motor neurons into the muscle and evaluate whether stress in the motor neuron perikaryon leads to detectable pathology at the NMJ.
However differential readout allows the scaling up from a single cell to a multi-cell device with no loss of time resolution; this becomes increasingly important for the highly segmented detectors that are being built today, both for particle and for medical instrumentation.
The double side readout allows also to improve the time of flight capability of the detector due to the possibility to correct the difference in the length of the optical light path between the scintillation point and the photodetector [15].
In addition, the uninterrupted readout allows for the rapid extraction and automated curation of conserved DNA from the genome of interest.
PTM, being a passive readout, allows for the measurement of the mechanical properties of cells without requiring direct contact with the cell.
The quantitative readout allows specifically interacting proteins to be distinguished from contaminants and also identifies low-affinity interactions that might not be apparent in conventional purifications.
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