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A major confounding issue in this regard is the growing realization that the pathogenesis of both human and animal prion diseases involves the propagation of protease-sensitive disease-related isoforms of PrP [17] [27] and that a substantial fraction of prion infectivity may be readily sensitive to protease degradation [25].
These results show that disease-related PrP comprises up to 85% of total PrP present in RML mouse brain homogenate; however, the majority (∼75%) of these disease-related PrP isoforms are readily sensitive to rapid digestion by PK.
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Moreover, through integrating with an isothermal amplification technique of rolling circle amplification (RCA), this programming catalytic DNA self-assembly strategy readily achieves sensitive and selective biosensing of initiator.
However, with human or other tissues that may not be readily available, sensitive radioactive hybridization techniques offer attractive opportunities, reducing the need for target or signal amplification.
5, 94 The requirement for more readily available, sensitive, and specific diagnostic tools for detecting and differentiating porcine Taenia species in the Asian context, as well as understanding the true prevalence and burden of NCC in the region, is urgently required.
However, these tests are sensitive, readily available, most useful and prognostically significant when they are monitored serially [14].
Ecological response variables that are readily quantified and sensitive to variation and alteration in flow regimes are critical to the application of environmental flow frameworks such as ELOHA.
Natural auxins are rapidly degraded by the plant, but auxinic herbicides are not readily metabolized by sensitive plants, and this probably leads to lasting effects on gene expression.
First, we showed that C. elegans takes up Mn readily and is sensitive to Mn exposure, exhibiting developmental delay, excretory cell and osmoregulatory defects which can be related to kidney and bladder defects observed in rodents [83], [84] and man [44].
In contrast, drug resistance profiles can be readily determined using sensitive and automated radiometric methods or by DNA-based technologies, but these can be time-consuming and expensive, limiting their applicability in the developing world where the vast majority of TB cases occur [5].
The most sensitive, readily identified, positively staining organs for IHC are the kidney, liver, lung, spleen, and small intestine.
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