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Proteins can readily diffuse even into highly condensed heterochromatin10,11,12, and inert diffusion probes of the size of large protein complexes readily entered condensed chromatin13,14.
These results showed that (1) [14C]7m6CP readily entered the brain, (2) it efficiently and specifically transformed to the GSH conjugate within the brain, and (3) after [14C]7m6CP disappearance, the clearance of radioactivity represented the only efflux of GSH conjugate.
In vivo studies in mice showed that URB937 (25 mg kg−1) readily entered the brain and spinal cord of Abcg2-deficient mice following intraperitoneal administration, whereas the same dose of drug remained restricted to peripheral tissues in wild-type mice.
The group then mixed the siRNAs with a type of fat molecule and applied it topically to the genitalia of 20 female mice, where the siRNAs readily entered cells of the vagina and cervix.
As the group's founders point out, this is a form of debt which is neither sought out nor readily entered into -- far from it.
These suggested that scFv 22C4 had readily entered the brain and labeled amyloid plaques in vivo.
Similar(43)
Would timid Carla so readily enter that frightening arena?
The former can readily enter the pores, but the latter are unable to penetrate.
Medium-chain fatty acids are soluble in water and readily enter the micelles.
Carmakers may find, for example, that Chinese consumers would more readily enter a car that protected themselves over pedestrians.
Wild rats can be safely removed from cages using heavy cloth bags that the animals readily enter.
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