Initial hopes for improved narcolepsy medicines that replace hypocretin have faded, because studies showed that the molecule did not readily cross the blood-brain barrier.
Saline purgatives are salts containing highly charged ions that do not readily cross cell membranes and therefore remain inside the lumen, or passageway, of the bowel.
It all sounded pleasant, but not the kind of thing you'd readily cross the howling six-lane purgatory of West Street for.
Hydrogen fluoride can readily cross cell membrane and acts like a proton conductor.
Moreover, it will not readily cross the cell membrane by passive diffusion.
In contrast, invasive species readily cross borders as long as there is suitable habitat on the other side [1].
These experiments suggest that dietary NA and is not readily transferred across the placental barrier but does readily cross the mammary epithelium and is incorporated into milk SM.
The results indicate that potassium ions readily cross the water/liquid membrane interface, whilst sodium ions are largely excluded from the membrane.
Literature precedents indicate that lipophilic drugs readily cross the BBB, although other chemical characteristics, including the number of hydrogen bonds, molecular weight, polar surface area, and molecular size, are also known to be critical to passive transport.
CGRP does not readily cross the blood brain barrier (BBB) [29, 30] and it was suggested that, even if CSD cause release of CGRP locally, it did not cross the BBB into the venous circulation in significant concentrations [27].
