Your English writing platform
Discover LudwigExact(7)
They are stringently temperature sensitive but senescence can be readily bypassed by inactivation of the p53-p21 or the p16-pRB pathway [ 16].
On the other hand, the bulkier N-(2′-deoxyguanosin-8-yl -2-acetylaminofluorene (AAF) analogues cannot be readily bypassed and thus stall DNA synthesis.
These cells are immortal but undergo a rapid irreversible arrest upon activation of the p53-p21 and p16-pRB pathways that can be readily bypassed upon their inactivation.
Yet, published reports indicate that both S-cdG and S-cdA are readily bypassed by the Y-family DNA polymerase pol η from yeast and human.
When facing endogenous damage, the replication fork with ε tightly bound to α would stall, because the translesion polymerase does not have access to the β clamp in QLSLPL and the damage could not be readily bypassed.
However, we speculate that the lesions that are readily bypassed by pol ν may have significant conformational flexibility and thus, can be accommodated without distorting DNA−enzyme interactions within the pol active site.
Similar(53)
This conclusion is further supported by the observation that FtsK hexamers readily bypass individual catalytically inactive ATPase subunits (Crozat et al., 2010).
Having demonstrated that pol ν can readily bypass N-dA PCLs, we hypothesized that it may also be able to carry out TLS past other N-dA major groove adducts, including N-dA− N-dA ICLs.
Our findings corroborate the view that the mechanical obstacles of epidermal thickness and waxy deposition could readily be bypassed during haustorial penetration when the surface porosity of the leaves is high (Gabler et al. 2003).
In addition, metabolic networks can be quite resilient to elimination of individual reactions in any given environment [ 13, 14, 16, 22, 26, 40- 44], partly because the blocked reactions can readily be bypassed through alternative metabolic routes.
Still our (lack of) findings provide some support that older individuals who persistently bring less severe conditions to the ED may be electing to bypass readily available community-based alternatives.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com